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KMID : 1102220160350010015
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Kidney Research and Clinical Practice
2016 Volume.35 No. 1 p.15 ~ p.21
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Direct vascular actions of quercetin in aorta from renal hypertensive rats
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Choi Seok
Ryu Kwon-Ho
Park Sang-Hag
Jun Jae-Yeoul
Shin Byung-Chul
Chung Jong-Hoon
Yeum Cheol-Ho
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Abstract
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Background: Chronic treatment with the dietary flavonoid quercetin is known to lower blood pressure and restore endothelial dysfunction in animal models of hypertension. This study investigated the direct effects of quercetin on vascular response in chronic 2-kidney, 1-clip (2K1C) renal hypertensive rats. The effects of antioxidant vitamin ascorbic acid on the vasoreactivity were also examined.
Methods: 2K1C renal hypertension was induced by clipping the left renal artery; age-matched rats that received sham treatment served as controls. Thoracic aortae were mounted in tissue baths for the measurement of isometric tension.
Results: Relaxant responses to acetylcholine were significantly attenuated in 2K1C rats in comparison with sham rats. Quercetin or ascorbic acid augmented acetylcholine-induced relaxation in 2K1C rats, whereas no significant differences
were noted in sham rats. The relaxation response to sodium nitroprusside was comparable between 2K1C and sham rats, and sodium nitroprussideeinduced relaxation was not altered by quercetin or ascorbic acid in either group. The contractile
response to phenylephrine was significantly enhanced in 2K1C rats compared with sham rats. Phenylephrine-induced contraction was inhibited by pretreatment with quercetin or ascorbic acid in 2K1C rats, whereas neither chemical
affected responses in sham rats. Nw-nitro-L-arginine methyl ester markedly augmented the contractile response to phenylephrine in sham rats, whereas no significant differences were observed in 2K1C rats. Quercetin or ascorbic acid did
not affect phenylephrine-induced contraction in the presence of Nw-nitro-L-arginine methyl ester in either 2K1C or sham rats.
Conclusion: Acute exposure to quercetin appears to improve endotheliumdependent relaxation and inhibit the contractile response, similar to the effect of ascorbic acid in 2K1C hypertension. These results partially explain the vascular beneficial effects of quercetin in renal hypertension.
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KEYWORD
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Antioxidant, Quercetin, Renal hypertension
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